- “Genome organization and DNA accessibility control antigenic variation in trypanosomes” – read here; Also read the story behind the paper here
- We have received a 4-year Israel Science Foundation Individual Research Grant!
- First paper from our lab:“Three invariant Hi-C interaction patterns: applications to genome assembly” – read here
- Article in The Atlantic about the implications of Hi-C-based genome assembly
About the Lab
Genomes carry genetic information. But genomes are not just abstract information: they are physically manifested as extremely long molecules that are intricately organized in the nucleus of every cell. The spatial organization of the genome is closely related to how it is accessed, regulated and activated by cellular machinery. We study this profound connection between genetic (and epigenetic) information and its physical organization.
The Lab of Genome Structure & Function, led by Dr. Noam Kaplan, uses a combination of experimental and computational methods to gain a mechanistic understanding of how the genome encodes its organization and how this organization conveys biological function. Read more about our research here.