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Lab News
  • Our work has been featured in a Haaretz article about 3D genome organization!
  • New paper: “Attenuated chromatin compartmentalization in meiosis and its maturation in sperm development” – read here. On the cover of Nature Structural & Molecular Biology
  • Congratulations to Haia for winning the 1st prize for her poster at the Genetics Society of Israel Annual Meeting GSI2019!
  • New paper: “Genome organization and DNA accessibility control antigenic variation in trypanosomes” – read here; Also read the story behind the paper here.
  • We have received a 4-year Israel Science Foundation Individual Research Grant!
  • New paper: “Three invariant Hi-C interaction patterns: applications to genome assembly” – read here.
NSMB cover
Our Research

Genomes carry genetic information. But genomes are not just abstract information: they are physically manifested as extremely long molecules that are intricately organized in the nucleus of every cell. The spatial organization of the genome is closely related to how it is accessed, regulated and activated by cellular machinery. We study this profound connection between genetic (and epigenetic) information and its physical organization.

Our research combines experimental and computational methods to gain a mechanistic understanding of how the genome encodes its organization and how this organization conveys biological function in various biological systems and diseases. Read more about our research here.

 

E-mail: noam.kaplan@technion.ac.il